Göttingen Graduate Center for Neurosciences, Biophysics, and Molecular Biosciences

Wintermeyer, Wolfgang, Prof. Dr.

Professor of Molecular Biology, Max-Planck-Fellow/Group leader


  • 1962-1969: Studies of Chemistry, LMU München; Grade Dipl.-Chem.
  • 1972: Dr. rer. nat., LMU München
  • 1972-1982: Research Assistant, LMU München
  • 1979: Dr. med. habil., LMU München
  • 1982-1987: Heisenberg-Fellow
  • 1985: Associate Professor, LMU München
  • 1987-2009: Full Professor for Molecular Biology, University of Witten/Herdecke
  • 1991-2007: Dean Faculty of Life Sciences, University of Witten/Herdecke
  • 2009: Professor emeritus and Max-Planck-Fellow

    • Major Research Interests
    Research interests of the group are focused on various aspects of ribosomal protein synthesis. We are studying the functions of GTPases on the ribosome, in particular of elongation factor G (EF-G). EF-G has two distinct functions in protein synthesis: it catalyzes the translocation of tRNA on the ribosome and, together with ribosome recycling factor (RRF), promotes the dissociation of the ribosome into subunits (“ribosome recycling”) after the termination of protein synthesis. We are working on the molecular mechanisms of both processes. One major question is how the energy of GTP hydrolysis and release of inorganic phosphate is coupled to conformational rearrangements of the ribosome. In another project we are examining the function of the signal recognition particle (SRP) in the biosynthesis of proteins to be inserted into the bacterial plasma membrane. SRP binds to ribosomes translating membrane proteins and, by an interaction with the SRP receptor, targets those ribosomes to the translocation pore in the membrane. We are studying the interactions between these components and the role of GTP hydrolysis by SRP and the SRP receptor in the targeting process. We use methods of biochemistry and molecular biology as well as biophysical methods, such as fluorescence spectroscopy (FRET), rapid kinetics (stopped flow, quench flow), isothermal calorimetry, single-molecule fluorescence and others.

    Homepage Department/Research Group
    https://www.mpinat.mpg.de/wintermeyer


    ORCID: 0000-0001-5119-8481